The phosphate salt of codeine takes place as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in water and a little soluble in Liquor. The molecular body weight is 406.37. Its molecular system is C18H21NO3•H3PO4 • ½ H2O, and it's the next chemical structure.
Severe Negative effects might be extra likely in older Grown ups and those who are overweight, malnourished, or debilitated.
That can help avoid withdrawal, your health practitioner could lessen your dose slowly and gradually. Withdrawal is more probable For those who have used this medication for many years (more than a few weeks) or in higher doses. Explain to your health care provider or pharmacist instantly if you have withdrawal.
Tend not to increase your dose or use this item far more normally or for lengthier than prescribed. Your issue will likely not enhance any more rapidly, along with your hazard of Negative effects will enhance.
Clinical Things to consider Fetal/Neonatal Adverse Reactions Extended usage of opioid analgesics during pregnancy for professional medical or nonmedical uses can result in physical dependence inside the neonate and neonatal opioid withdrawal syndrome Soon immediately after birth.
If this SPL incorporates inactivated NDCs listed from the FDA initiated compliance motion, They are going to be specified therefore.
Be sure you know the way to acquire this product or service and what other medication you must prevent having with it. See also Drug Interactions portion. Get clinical aid instantly if any of these very critical Uncomfortable side effects manifest: slow/shallow breathing, uncommon lightheadedness, extreme drowsiness/dizziness, problems waking up.
To help stop withdrawal, your health care provider might decreased your dose bit by bit. Withdrawal is much more possible if you have used this medication for years (various weeks) or in significant doses. Explain to your physician or pharmacist immediately if you have withdrawal.
If adrenal insufficiency is diagnosed, address with physiologic substitute doses of corticosteroids. Wean the affected individual off in the opioid to permit adrenal purpose to Recuperate and proceed corticosteroid cure right until adrenal operate recovers. Other opioids may very well be tried using as some instances documented utilization of another opioid without recurrence of adrenal insufficiency. The data accessible will not recognize any individual opioids as getting extra more likely to be involved with adrenal insufficiency.
Propulsive peristaltic waves in the colon are lessened, when tone could possibly be improved to The purpose of spasm causing constipation. Other opioid-induced effects might incorporate a reduction in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase.
Get this medication by mouth with or without foodstuff as directed by your health practitioner, ordinarily every four to six several hours as required. This medication could be taken with food items if stomach upset happens. Consume loads of fluids when you use this medication unless otherwise directed by your medical professional.
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Codeine was not mutagenic within the in vitro bacterial reverse mutation assay or clastogenic inside the in vitro Chinese hamster ovary (CHO) mobile chromosomal aberration assay.
The dosage of Promethazine with Codeine Oral Option shouldn't be improved if cough fails to respond; an unresponsive cough ought to be reevaluated for feasible underlying pathology.